USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: O00487 USC-OGP 2-DE database:  O00487 O00487 General information about the entry View entry in simple text format Entry name PSDE_HUMAN Primary accession number O00487 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=26S proteasome non-ATPase regulatory subunit 14; EC=3.4.19.-; AltName: Full=26S proteasome regulatory subunit RPN11; AltName: Full=26S proteasome-associated PAD1 homolog 1;. Gene name Name=PSMD14 Synonyms=POH1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0752: pI=5.94; Mw=33047 SPOT OGP-0767: pI=5.92; Mw=31210 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1221: pI=5.94; Mw=35753 SPOT OGP-1226: pI=6.21; Mw=34957 Cross-references UniProtKB/Swiss-Prot O00487; PSDE_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSDE_HUMAN Primary accession number O00487 Secondary accession number(s) B3KNW2 O00176 Sequence was last modified on  July 1, 1997 (version 1) Annotations were last modified on  March 15, 2017 (version 156) Name and origin of the protein Description RecName: Full=26S proteasome non-ATPase regulatory subunit 14; EC=3.4.19.-; AltName: Full=26S proteasome regulatory subunit RPN11; AltName: Full=26S proteasome-associated PAD1 homolog 1; Gene name Name=PSMD14 Synonyms=POH1 Encoded on Name=PSMD14; Synonyms=POH1 Keywords 3D-structure; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; Hydrolase; Metal-binding; Metalloprotease; Phosphoprotein; Protease; Proteasome; Reference proteome; Ubl conjugation pathway; Zinc. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U86782; AAC51866.1; -; mRNA EMBL AK055128; BAG51474.1; -; mRNA EMBL CH471058; EAX11370.1; -; Genomic_DNA EMBL BC066336; AAH66336.1; -; mRNA CCDS CCDS46437.1; -; . RefSeq NP_005796.1; NM_005805.5; . UniGene Hs.740477; -; . PDB 5GJQ; EM; 4.50 A; V=1-310 PDB 5GJR; EM; 3.50 A; 9/V=1-310 PDB 5L4K; EM; 4.50 A; V=1-310 PDB 5T0C; EM; 3.80 A; Ac/Bc=1-310 PDB 5T0G; EM; 4.40 A; c=2-310 PDB 5T0H; EM; 6.80 A; c=2-310 PDB 5T0I; EM; 8.00 A; c=2-310 PDB 5T0J; EM; 8.00 A; c=2-310 PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4K; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal O00487; -; . SMR O00487; -; . BioGrid 115508; 110; . IntAct O00487; 67; . MINT MINT-5003743; -; . STRING 9606.ENSP00000386541; -; . BindingDB O00487; -; . ChEMBL CHEMBL2007629; -; . iPTMnet O00487; -; . PhosphoSitePlus O00487; -; . SwissPalm O00487; -; . BioMuta PSMD14; -; . OGP O00487; -; . REPRODUCTION-2DPAGE IPI00024821; -; . EPD O00487; -; . MaxQB O00487; -; . PaxDb O00487; -; . PeptideAtlas O00487; -; . PRIDE O00487; -; . TopDownProteomics O00487; -; . Ensembl ENST00000409682; ENSP00000386541; ENSG00000115233; . GeneID 10213; -; . KEGG hsa:10213; -; . UCSC uc002ubu.4; human; . CTD 10213; -; . DisGeNET 10213; -; . GeneCards PSMD14; -; . HGNC HGNC:16889; PSMD14; . HPA HPA002114; -; . HPA HPA003828; -; . MIM 607173; gene; . neXtProt NX_O00487; -; . OpenTargets ENSG00000115233; -; . PharmGKB PA134957776; -; . eggNOG KOG1555; Eukaryota; . eggNOG COG1310; LUCA; . GeneTree ENSGT00730000111116; -; . HOGENOM HOG000183690; -; . HOVERGEN HBG053742; -; . InParanoid O00487; -; . KO K03030; -; . OMA TQQSFES; -; . OrthoDB EOG091G0CMC; -; . PhylomeDB O00487; -; . TreeFam TF105748; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-5689901; Metalloprotease DUBs; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMD14; human; . GeneWiki PSMD14; -; . GenomeRNAi 10213; -; . PRO PR:O00487; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000115233; -; . CleanEx HS_PSMD14; -; . ExpressionAtlas O00487; baseline and differential; . Genevisible O00487; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0031597; C:cytosolic proteasome complex; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0022624; C:proteasome accessory complex; ISS:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0008541; C:proteasome regulatory particle; lid subcomplex; IMP:UniProtKB GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0061133; F:endopeptidase activator activity; IMP:UniProtKB; . GO GO:0061578; F:Lys63-specific deubiquitinase activity; TAS:Reactome; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0008237; F:metallopeptidase activity; TAS:UniProtKB; . GO GO:0070628; F:proteasome binding; IDA:UniProtKB; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB; . GO GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:UniProtKB; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0070536; P:protein K63-linked deubiquitination; IMP:UniProtKB; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061136; P:regulation of proteasomal protein catabolic process; IMP:UniProtKB; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0045471; P:response to ethanol; IEA:Ensembl; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:UniProtKB; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome InterPro IPR000555; JAMM/MPN+_dom; . InterPro IPR024969; Rpn11/EIF3F_C; . Pfam PF01398; JAB; 1; . Pfam PF13012; MitMem_reg; 1; . SMART SM00232; JAB_MPN; 1; .

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